MEG3 is defined as a tumor suppressor, but also regulates the balance of Treg cells and Th17 cells; downregulation of MEG3 increases forkhead box P3 (FOXP3) expression and inhibits retinoic acid receptor-related orphan receptor γt (RORγt) expression, to tip the balance in favor of Treg cells [45,46]. This evidence concerns the gene MEG3 and neoplasm.