Similarly, α-catenin was able to limit the YAP1 transcriptional activity in human squamous cell carcinoma [158] and control the proliferation of both cardiomyocyte [159] and epidermal stem cell [152], further proving the role of cadherin-catenin complex in the regulation of Hippo-YAP signaling pathway. The gene discussed is YAP1; the disease is squamous cell carcinoma.