SMAD3 and non-small cell lung carcinoma: Jo et al. demonstrated that kaempferol reverses TGF-β1-induced SNAIl induction and restores E-cadherin expression through selectively impeding AKT1-mediated phosphorylation of Smad3 at Thr179 residue in human NSCLC cells which weakens Smad3 binding to the SNAIL promoter [265].