Then we quantified the methylation levels of LMX1A, SOX1, and ZNF177 in 151 pairs of CRC tissues and found that the DNA methylation levels of LMX1A, SOX1, and ZNF177 in 151 CRC tissue samples were significantly higher than those in the corresponding nontumor tissue samples (Figure 1D). The gene discussed is SOX1; the disease is colorectal carcinoma.