For CRC screening, a stool-based screening test for N-Myc downstream-regulated gene 4 (NDRG4) and bone morphogenic protein 3 (BMP3) methylation, as well as a blood-based assay for septin 9 (SEPT9) methylation, were approved by the United States Food and Drug Administration [8,9,10,11]. Here, SEPTIN9 is linked to colorectal carcinoma.