CAV2 and ischemia: As a matter of fact, using mechanical blebbing injury during pipette aspiration-induced membrane stretch (to simulate the damages imposed to the cardiac smooth muscle cells during ischemia, reperfusion, inflammation, a.o.), Joós et al. showed that the resulting lipid membrane disruption and/or fluidization are linked to increased Cav channel activation, which could explain the Cav channel leakiness and arrhythmias in pathologies [286].