Two NAOs, neoagaroteraose (signed as NA4) and neoagarohexaose (signed as NA6), have been reported to be able to ameliorate obesity and the obesity-related metabolic defects, such as hyperlipidemia, steatosis, insulin resistance, and glucose intolerance in obese mice, by means of the induction of adiponectin [21]. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.