Different Notch pathway-related genes such as delta like canonical Notch ligand 3 (DLL3) Hes family BHLH transcription Factor 6 (HES6), deltex E3 ubiquitin ligase 1 (DTX1), and jagged canonical notch ligand 2 (JAG2) are up-regulated, while others such as Notch 2 and 4 receptors are down-regulated in NEPC, indicating the multifaceted role of Notch signaling pathway in PCa. This evidence concerns the gene HES6 and posterior cortical atrophy.