Deregulation of Notch signaling pathway (e.g., Notch receptors, 1–4; ligands, jagged-1, jagged-2, and δ-like proteins 1, 3, and 4; and Notch target genes, HEY1 and HES1) is observed in several solid malignancies, including PCa [130]. The gene discussed is JAG2; the disease is posterior cortical atrophy.