On the other hand, C1 subtype HB tumors are characterized by the overexpression of genes such as GLUL, RHBG, CYP2E1, and CYP1A1. It is also important to note that different sets of Wnt/beta-catenin-targeted genes are overexpressed in the two HB subtypes [13]. This evidence concerns the gene CYP2E1 and hemoglobin measurement.