ITGAM and neoplasm: Using tumor samples obtained from the mice, we demonstrated that treatment with 0.5 mg/kg/day cisplatin alone, 3 mg/kg/day PG2 alone, or PG2/cisplatin combination down-regulated the expression of NF-κB and CD31 proteins mildly, moderately, and strongly, respectively, while up-regulating CD11b protein expression level in increasing order of magnitude (Figure 5D).