IL10 and neoplasm: Furthermore, we demonstrated that PG2 significantly repressed anti-inflammatory IL-10-induced proliferation of tumor-promoting CD206+ cells, compared with the control group (~2.58-fold, p < 0.01), and this was akin to the PG2-induced 2.93-fold (p < 0.01) decrease in CD206 expression by M2 macrophages cultured in CCCM (Figure 4B).