DHEA suppresses type 2 immune responses [65]: in female ovalbumin-sensitized asthma model mice, DHEA administration reduced eosinophil infiltration into the lung; serum ovalbumin-specific IgE levels; and the expression of IL-4, IL-5, and IL-13 and type 2 chemokines CC-chemokine ligand 1 (CCL1) and CCL24 in bronchoalveolar lavage fluid but increased IFN-γ production in ovalbumin-activated splenocytes [59]. Here, IGHE is linked to asthma.