ESR2 and autoimmune thyroid disease: Diarylpropionitrile, a specific agonist of ERβ and not of ERα, in vivo enhanced IL-17A, IL-21, and RORγt mRNA levels in splenocytes of experimental autoimmune thyroiditis model mice through binding of the agonist-activated ERβ to IL-17A and IL-21 gene promoters [29].