In a model developed by Varela-Eirin et al. [155], an epithelial-to-mesenchymal transition, which is regulated by TGFβ, IKK-2/IκBα/NFκB and Wnt proteins, takes place in osteoarthritis [156]; resulting a fibrogenic (re-differentiated) phenotype with increased N-cadherin, vimentin, fibronectin, collagen and MMP levels. Here, TGFB1 is linked to osteoarthritis.