Wu et al. [84] recently reported that sclerostin secretion by chondrocytes is not consistent in the various stages of osteoarthritis: in early disease, sclerostin secretion by pre-hypertrophic chondrocytes is infinitesimal, suggesting that during the onset of osteoarthritis, sclerostin is secreted by subchondral osteocytes into the cartilage, whereas by mid-stage and late-stage disease, hypertrophic chondrocytes have progressively more sclerostin secretory properties. Here, SOST is linked to osteoarthritis.