The strategy of PD-L1 blockade had the effect of increasing the potency of the anti-tumor effects of the E7 antigen-specific protein vaccine, which could directly increase the susceptibility of tumor cells to killing and indirectly enhance the antigen-specific CD8+ T-cell responses through promoting DC maturation and M1-like polarization of macrophages to overturn the immuno-suppressive tumor microenvironment in an E7-expressing tumor model. This evidence concerns the gene CD8A and neoplasm.