Lin et al. showed that combination therapy of anit-PD-L1 Ab and Lm-LLO-E6 vaccine which secreted HPV-16 E6 antigen fused to listeriolysin O (LLO) pore-forming toxin by bacterial vector could exhibit potent anti-tumor efficacy against HPV-16 E6-positive human TL-1 lung cancer in nude mice [22]. Here, CD274 is linked to neoplasm.