A significant difference between CIN and MSI COADs is observed for genes located in chromosomes undergoing frequent BCNGs, such as CPSF1 (chr8q24.3), CPSF4 (chr7q22.1) and CSTF1 (Chr20q13.2). The gene discussed is CPSF4; the disease is cervical squamous intraepithelial neoplasia.