KRAS and neoplasm: In looking solely at KRAS G12/G13, we found a statistically significant enrichment in concordance when patients were treated with standard-of-care systemic therapies prior to tissue NGS or ctDNA analysis (chemotherapy-treated: 5/5 (100%) vs. chemotherapy-naïve: 3/9 (33%); p = 0.031), which suggests that these mutations are likely truncal in the clonal ancestry of tumor evolution and therapeutically viable.