Importantly, in line with previous studies pointing to a role of NS4A and NS4B in inhibition of neurogenesis and deregulation of the Akt-mTOR signaling pathway [51], this study also identified shared targets deregulated both by ZIKV infection and NS4B expression (e.g., MAP2, -6, DPYSL3, -5, CNTN2). Here, AKT1 is linked to Zika virus infectious disease.