Similarly, direct involvement of the NMD pathway in flavivirus is corroborated by the identification of the regulator of nonsense transcripts 1 (UPF1) among the ZIKV capsid interactors and the upregulation of several NMD substrate mRNAs upon ZIKV infection both in Huh7 and hNPC. Here, UPF1 is linked to Zika virus infectious disease.