With the evidence suggesting that circulating NKs could be recruited to the uterus during early pregnancy and undergo reprogramming in the uterine microenvironment [59], it is plausible to hypothesize that the tumor microenvironment with high levels of TGF-β and hypoxia can induce reprogramming of NK cells to dNK-like phenotype. This evidence concerns the gene TGFB1 and neoplasm.