Our study highlighted that CD11chiCD11b+ DCs possess functional abnormalities during SLE development and provided new insights into the possible role of mDCs in facilitating Tfh migration into germinal center to potentiate B cell responses via heightened TLR7 and TLR9 response upon stimulation of accumulated nucleic acids-containing immune complex during SLE development. Here, TLR7 is linked to systemic lupus erythematosus.