DEPDC5 and neoplasm: A crucial determinant of the activation state of Rag small GTPases, of relevance to the focus of this review, is the “GATOR” super-complex, composed of two complexes of opposing function: GATOR1 (containing DEP Domain Containing 5 (DEPDC5), Nprl2 and Nprl3, negatively regulating RagA:B, and considered an important tumor suppressor [29]); and GATOR2 (a positive regulator of the Rag complex composed of Mios; the WD Repeat Domain proteins WDR59 and WDR24; Seh1L and Sec13) [29].