NR1H3 and fatty liver disease: Sterol regulatory element binding protein-1c (SREBP-1c) is an important target gene of LXRα activation [122] and is a key transcription factor of lipogenic gene expression [123] The LXRα-SREBP-1c axis is an attractive target for the prevention and/or treatment of lipid anabolism networks both driving hepatic steatosis and supporting the high rates of growth and proliferation in different forms of cancer [124,125].