GSK3B and early-onset autosomal dominant Alzheimer disease: In recent study, I3M showed neuronal protective effects against β-amyloid (Aβ)-mediated apoptosis by inhibiting GSK-3β, which could be applied in the treatment of neurodegenerative diseases such as Alzheimer’s disease [16], because it directly inhibits important neuronal disease factors, including tau, α-synuclein, and Aβ [17].