TGFB1 and neoplasm: Numerous in vivo and in vitro studies have demonstrated that an increased expression of the MT-1 and MT-2 isoforms may potentiate tumor angiogenesis, e.g., by increasing the synthesis and expression of fibroblast growth factor (FGF), transforming growth factor (TGF-β), and vascular endothelial factor (VEGF), leading to better blood supply to the tumor and stimulating its growth [197,198].