This is in part because the tumor grows faster than the defenses develop, and also because cytotoxic substances are blocked by various substances secreted by the tumor, e.g., transforming growth factor β (TGF-β), interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), and prostaglandin E2 (PGE2) [27,28,29,30]. This evidence concerns the gene TGFB1 and neoplasm.