It has been reported that 10 min of TI can lead to a significant increase of mTOR activation in the rat hippocampus [53] and that the inhibition of the mTOR pathway can attenuate ischemic brain injury by inhibiting lipid peroxidation, microglial activation, and the generation of proinflammatory cytokines (IL-1β and TNF-α) in rat models of transient (90 and 120 min) middle cerebral artery occlusion and cardiac arrest-induced transient (6 min) global ischemia [54,55,56]. The gene discussed is TNF; the disease is cardiac arrest.