TNF and ischemia: In the HFD 2-min TI group, IL-1β and TNF-α levels were further significantly increased (about 2.4-fold, p < 0.001, and 2-fold, p < 0.001 of the HFD sham group, respectively) at 2 days post-ischemia and more significantly decreased (about 5.5-fold, p < 0.001, and 8.4-fold, p < 0.001 of the HFD sham group, respectively) at 5 days post-ischemia.