In the ND 2-min TI group, HNE immunoreactivity was significantly increased (about 130%, p < 0.05, and 132%, p < 0.05 of the ND sham group, respectively) at 2 and 5 days post-ischemia compared to that in the ND sham group (Figure 5B-b4,4B-b7,D). The gene discussed is ELANE; the disease is ischemia.