TNF and cholestasis: Despite the great importance of TNF-α [53,54,55], and given the complex network of many cytokines that play substantial roles in the homeostasis and injury of liver, IL-6 is a prominent cytokine because of its bidirectional effects, mainly pro-inflammatory ones, and importance as a mediator in the acute phase response and in chronic hepatic diseases, such as cholestasis, necrosis, and fibrosis, by its interaction with other cytokines.