Therefore, sex hormones, OC, or their metabolites, may influence the cytokine milieu by immune cells during liver damage [9], as is the case of LPS-induced cholestasis that activates hepatocytes to release pro-inflammatory cytokines, which in turn activate the Kupffer cells to promote liver damage, or even the very same drug-induced cholestatic process induced by these hormones or their metabolites; thus, sex hormones may act by direct and indirect immunomodulatory mechanisms to provoke or regulate cholestasis. This evidence concerns the gene BGLAP and cholestasis.