These included BRCA1 and BRCA2 and their interacting partners PALB2 and BAP1, and a cluster of chromatin modifiers including SMARCA4, SMARCB1 and SMARCE1. Consistent with its role in mitigating DNA damage caused by inappropriate G4 stabilization, the gene encoding Pol θ (POLQ), which is also mutated in human cancers (https://cancer.sanger.ac.uk/census) also sensitized cells to pyridostatin treatment [54]. The gene discussed is SMARCE1; the disease is cancer.