In this regard, mango phenolic compounds showed a chemotherapeutic potential for suppressing tumor growth in breast cancer xenografts in mice, lowering the expression of a plethora of tumor associated proteins such as PI3K, AKT, hypoxia inducible factor-1α (HIF1α), and vascular endothelial growth factor (VEGF) [16]. This evidence concerns the gene HIF1A and neoplasm.