AGT and achalasia-alacrima syndrome: We observed increased HIF-1α expression in TPMs from mouse CaPO4-induced aneurysms (21.73% ± 6.202% vs. 67.7% ± 2.195%, p < 0.001), AngII-induced aneurysms (5.572% ± 1.356% vs. 56.22% ± 5.458%, p < 0.001), and human AAAs (20% ± 4.952% vs. 82.8% ± 11.58%, p < 0.01) (Figure 5D–F, respectively).