Interestingly, novel findings of Sachez-Mut and colleagues indicate that PM20D1 (peptidase M20 domain containing 1) methylation and expression are dependent on the SNP rs708727, and that both the epigenetic regulation of PM20D1 and the genetic variation at rs708727 are linked to Alzheimer’s disease [25]. This evidence concerns the gene PM20D1 and Alzheimer disease.