This is supported here with upregulation of immune transcripts, for example, CXCL6, NR4A3 and SAA2-SAA4, becoming apparent at 48 h p.i. Immune related transcripts (ORM1, GM12250, SAA3, BGP5, CXCL9 and CD274) then dominated the majority of the top 10 upregulated transcripts at 72 h p.i., as the classical innate immune response to infection developed. Here, CD274 is linked to infection.