Although aggresome formation should promote the removal of unfolded proteins via the ALP (aggrephagy) [13], DCM hearts were characterized by a significantly reduced expression of Beclin 1, Atg5, and Atg7 (Figure 2A) and by a significant accumulation of p62SQSTM1, suggesting a discrepancy between aggresome formation and the ability of DCM hearts to remove aggregates (Figure 2B). This evidence concerns the gene ATG7 and familial dilated cardiomyopathy.