TNF and infection: Many of these proinflammatory mediators, including IL-6, MCP-1, TNFα, IFNγ, RANTES and IL-1β, were also present at high concentrations on days 4 and 6 of infection in the spleen (Figure 5, Supplementary Figure S1), a major target tissue for SFTSV replication (Figure 6) and pathology (Figure 7), as well as other tissues (Supplementary Table S2).