In the current study, we investigated (1) the correlation between PRL-3 and stathmin in myeloid leukemia; (2) the biological behavior in myeloid leukemia cells after PRL-3-silencing; and (3) the roles of stathmin in PRL-3 mediated myeloid leukemia pathogenesis. Here, STMN1 is linked to myeloid leukemia.