Although there is still a lack of a clear molecular explanation for the adverse effects of statin therapy on insulin sensitivity, this association has been reported in other studies: Duvniak et al showed that statin therapy introduction was associated with 36% increased risk of reduced insulin sensitivity after adjustment for confounding risk factors in subjects with type 1 diabetes; these findings were observed after 56 months of statin exposure (47). Here, INS is linked to type 1 diabetes mellitus.