In addition, EHM inhibited hyperlipidaemia by restoring the expression of genes and proteins related to DNA repair and energy metabolism, and proteins such as Hdac2, Xrcc2, Xrcc3, Uhrf1, and Prkar2b were identified as molecular targets playing key roles in ameliorating hyperlipidaemia. Here, XRCC3 is linked to hyperlipidemia.