Although significantly downregulated molecules represent probable liver-specific ECM components, overexpressed proteins are of great interest; some of them were previously linked to the development and progression of colorectal cancer, including versican (9, 10a), osteonectin (1, 51), galectins (3, 41, 48), and protein of the S100 family (24, 49). This evidence concerns the gene VCAN and colorectal cancer.