MBP and Hypertension: 2009; Ewer et al. 2014; Jacob et al. 2016; Narayan et al. 2017), SU-treated mice exhibited significantly elevated SBP, MBP, DBP, and lowered LVEF and FS, compared with vehicle-treated mice, indicating that SU triggered hypertension and LVD in mice (Figure 1(A,B)). Moreover, co-treatment of SU and TMZ completely reversed these effects (Figure 1(A,B)). Furthermore, TUNEL analysis showed that SU induced increased cell death rates in cardiomyocytes (Figure 1(C)). Once again, this increase in cell death was significantly alleviated by TMZ co-treatment (Figure 1(C)).