HADHA and diabetic cardiomyopathy: The primary molecular inhibition target of TMZ is HADHA, through which TMZ switches myocardial energy metabolism from β-oxidation of fatty acids to the faster and more efficient glucose utilization, supplying the heart with a more proficient energy turnover, making the heart more durable under conditions of energy shortage such as ischemia, diabetic cardiomyopathy or drug toxicity (Chrusciel et al.