INS and type 2 diabetes mellitus: 2003; Jensen et al. 2008). A previous study has also shown down-regulation of PI3K signaling in the skeletal muscle of type 2 diabetic KKAy mice (Zhang et al. 2016). Met-mediated decreased glucose has mainly been attributed to its ability to increase peripheral insulin sensitivity and/or promote insulin-mediated glucose uptake in the skeletal muscle of type 2 diabetic patients. These effects are in part mediated by stimulating Glut4 translocation and promoting insulin to bind to its receptors on the cell surface (Choi and Kim 2010).