The outlying variants (rs6859 and rs7254892) for LDL-C and AD are located near to the APOE locus and are associated with AD risk with odds ratios of 1.40 (95% CI: 1.35, 1.44) and 1.28 (95% CI: 1.15, 1.44) respectively [41]. The gene discussed is APOE; the disease is Alzheimer disease.