Importantly, these pro‐tumorigenic effects were attenuated by exogenous administration of Klotho, a classical anti‐aging protein (Kuro‐o et al., 1997; Kurosu et al., 2005) which we, and others, have previously shown to be tumor suppressive (Ibi et al., 2017; Ligumsky et al., 2015; Lojkin et al., 2015; Pan et al., 2011; Wang et al., 2011). Here, KL is linked to neoplasm.