Also, analysis of paired normal colon tissue and colon cancer (n = 26) showed that mRNA levels of EphB2, EphB3, EphB4, and EphA4 are significantly lower in the normal tissue than in the adjacent cancer (Fig. 1C), whereas levels of EphrinB2 and EphB1 are similar (Fig. 1C). The gene discussed is EPHA4; the disease is malignant colon neoplasm.