We examined the expression of EphrinB2 ligand and the EphrinB2 signaling receptors (EphB1, EphB2, EphB3, EphB4, and EphA4) (Kania and Klein, 2016; Noberini et al., 2012b) in colorectal carcinoma. The gene discussed is EPHB2; the disease is colorectal carcinoma.