The Clinical Proteomic Tumor Analysis Consortium (CPTAC)‐2 (https://proteomics.cancer.gov/data-portal) results mirrored the results of transcriptome analysis in showing that EphB2, EphB3, and EphB4 proteins are significantly more abundant in colon cancer compared to the adjacent normal colon tissue (n = 100; EphB1 and EphA4 proteins were not reported, presumably attributable to no detection). This evidence concerns the gene EPHB3 and malignant colon neoplasm.