EPHA4 and colonic neoplasm: Also, analysis of paired normal colon tissue and colon cancer (n = 26) showed that mRNA levels of EphB2, EphB3, EphB4, and EphA4 are significantly lower in the normal tissue than in the adjacent cancer (Fig. 1C), whereas levels of EphrinB2 and EphB1 are similar (Fig. 1C).