Lineage‐tracing experiments have shown that the leucine‐rich repeat‐containing G‐protein‐coupled receptor‐5‐positive (Lgr5+) intestinal stem cells, which normally reside at the bottom of the intestinal crypt, are the cells of origin of intestinal adenomas, the precursors of colorectal cancer (Barker et al., 2007; Schepers et al., 2012). This evidence concerns the gene LGR5 and colorectal cancer.