Depletion of Lgr5+ cells from colorectal carcinomas reduced tumor growth in mice, but did not lead to tumor regression (Shimokawa et al., 2017; de Sousa e Melo et al., 2017), and this phenotype coincided with the more differentiated Lgr5− cancer cells regaining their proliferative capacity and Lgr5+ status (Shimokawa et al., 2017; de Sousa e Melo et al., 2017). This evidence concerns the gene LGR5 and colorectal carcinoma.