MAP1LC3B and colorectal carcinoma: Additionally, the autophagy inducer rapamycin (rapa) (Fulda and Kogel, 2015; Marino et al., 2014) induced accumulation of LC3B in colorectal carcinoma cells, albeit to a somewhat lower degree than NVP and NVP‐Iso, and expectedly reduced constitutive activity of the mammalian target of rapamycin that was not altered by NVP and NVP‐Iso (Fig. S8A).