TIMP1 and colorectal carcinoma: It is conceivable that TIMP‐1 may cause increased activity in the Ras signaling axis in cells expressing oncogenic Ras, resulting in persistent enhanced signaling through this pathway, which would explain the worse outcome we observed in CRC patients in association with TIMP‐1 expression (Tarpgaard et al., 2016), but further studies will be needed to clarify these observations.