PRL and hyperprolactinemia: There was a moderately increased fracture risk of typical antipsychotics but not risperidone compared with other atypical antipsychotics, and since risperidone is known for its potential to increase prolactin, the increased risk associated with typical antipsychotics is unlikely to have been caused by hyperprolactinemia but perhaps more likely residual confounding related to lifestyle factors that could not be controlled.