Several of our findings reinforce and extend prior reports, showing that MOG antibodies are common at onset in pediatric ADS,2,21 particularly among younger children and those who present with ADEM or ON.3,22,23,24 We also confirmed a bimodal distribution of clinical presentations and MRI features in anti-MOG antibody–positive children, with younger patients being more likely to present with ADEM and/or a large number of ill-defined MRI lesions and older children more often presenting with ON and no or few well-defined brain lesions.2,25. The gene discussed is MOG; the disease is acute disseminated encephalomyelitis.