Our study suggests a potential novel strategy to overcome such resistance by showing that SIP-SII, a chemically sulfated polysaccharide isolated from the ink of the cuttlefish Sepiella maindroni, inhibits Akt activation and sensitizes bladder cancer cells to the anti-tumor actions of the FGFR inhibitor AZD4547. Here, AKT1 is linked to urinary bladder carcinoma.