For instance, it was shown to repress lung metastasis of B16F10 melanoma xenografts in mice via inhibition of MMP2 [13], and to inhibit EGFR-Ras-MEK-MMP2 and EGFR-PI3K-MMP2 pathways in an EGF-dependent manner in KB cells [14]. The gene discussed is PIK3CA; the disease is melanoma.