Excitation/inhibition imbalance due to increased GABAergic tone is a hypothesized mechanism governing NF1-associated cognitive deficits (Diggs-Andrews and Gutmann, 2013), and GABAA receptor agonists increase rheobase (Rojas et al., 2011), so we investigated excitation/inhibition balance in putative dopaminergic neurons by measuring spontaneous inhibitory (sIPSC) and excitatory post-synaptic currents (sEPSC) in voltage clamp (Figure 3E). Here, NF1 is linked to Cognitive impairment.