CGAS and neoplasm: For instance, because cGAS promotes both tumorigenesis (Ahn et al, 2014; Dou et al, 2017; Bakhoum et al, 2018) and anti‐tumor immunity (Deng et al, 2014; Woo et al, 2014; Harding et al, 2017; Wang et al, 2017), pinpointing the extent and biological context in which the distinct subcellular functions of cGAS contribute to these processes, and how these cGAS functions may be manipulated, will be beneficial for achieving the desired outcome of DNA damage‐ and immune‐based anti‐tumor therapies.