EGFR and gastric cancer: For example, trastuzumab targets HER2 receptors in breast and stomach cancer cells in order to inhibit their proliferation and survival [16], and cetuximab inhibits epidermal growth factor receptor (EGFR) in colorectal and lung cancer [17,18]; and (2) Immune effector functions that engage the Fc region of antibodies via Fc receptors (FcR) on immune cells.