As a trifunctional antibody, one Fab antigen-binding site binds T-cells via CD3 receptor, the other site binds tumor cells via the tumor antigen epithelial cell adhesion molecule (EpCAM) and the Fc region provides a third binding site to recruit and activate immune effector cells via binding to FcγRI, IIa and III receptors [154]. Here, EPCAM is linked to neoplasm.