CCR2 and neoplasm: These most recent approaches include functions such as an inducible caspase-based suicide mechanism to eliminate the CAR-T cells on demand [98], expression and secretion of T-cell activating cytokines [99], the incorporation of trafficking receptors such as CCR2 to help the T-cell home to tumor microenvironments [100] or the use of virus-specific T cells that recognize viral antigens which can be used as “vaccines” to increase the persistence of the CAR-T construct [101,102,103].