IGHE and colon adenocarcinoma: Rat CC531 colon adenocarcinoma cells [185], engineered to express the human FRα (CC531tFR), were administered i.v. to grow as multifocal syngeneic lung metastases, and rats were administered a rat surrogate for the mouse/human chimeric MOv18 IgE engineered with rat Fc domains and respective effector functions (rat MOv18 IgE).