Consistent with in vivo findings in the rat model, tumour cell cytotoxicity potentiated by mouse/human chimeric MOv18 IgE and human PBMC effector cells was associated with significantly elevated secreted mediators MCP-1, IL-10, and TNFα in co-culture supernatants, compared with either non-specific NIP IgE-treated or no antibody controls. This evidence concerns the gene TNF and neoplasm.