In vitro, mouse/human chimeric MOv18 IgE activated human peripheral blood mononuclear cells (PBMCs) to kill ovarian cancer cells, compared with background cancer cell death with nonspecific mouse/human chimeric anti-4-hydroxy-3-nitro-phenacetyl (NIP) IgE, or no antibody controls [179]. The gene discussed is IGHE; the disease is ovarian cancer.