TNF and neoplasm: In addition, a higher proportion of CD68+ macrophages from rat MOv18 IgE-treated tumours expressed intracellular IL-10, considered an M2 marker, compared with rat MOv18 IgG2b- and vehicle-treated groups, although this represented a smaller subset compared with the TNFα+ population, with a proportion of cells demonstrating double positivity (TNFα+/IL-10+) within the rat MOv18 IgE-treated cohort.