Exposure of the RBL SX-38 cells to MOv18 IgE alone did not induce significant degranulation; however cross-linking MOv18 IgE bound to the effector cell surface using either a polyclonal anti-IgE antibody or FRα-expressing cancer cells induced appreciable degranulation (Figure 10c) [182]. The gene discussed is FOLR1; the disease is cancer.