Radiolabeled nanobodies targeting tumor biomarkers such as the epidermal growth factor receptor (EGFR), carcinoembryonic antigen (CEA), mesothelin, prostate-specific membrane antigen (PSMA), CD20, or HER2 showed high specific tumor uptake (ranging typically between 2 and 10% IA/g, depending on the expression level of the target) in preclinical tumor models as soon as 1 h after administration, with tumor-to-blood ratios of up to 10–30 (Figure 1B,C) [23,35,38,41,42,45,48,49,53,54,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71]. The gene discussed is CEACAM5; the disease is neoplasm.