Proinflammatory cytokines released during cerebral ischemia activate ECs, leading to an increase in vesicles for transcellular transport and an increase in cell surface molecules associated with leukocyte recruitment [22] e.g., P-selectin and intercellular adhesion molecule 1 (ICAM-1), which mediate leukocyte rolling and adhesion, respectively [23,24]. The gene discussed is ICAM1; the disease is Cerebral ischemia.