GPR65 and colitis: Similarly, the expression of pro-inflammatory cytokines was elevated in GPR65−/− mice compared to wild-types in a colitis model, the same was observed for a T-cell transfer colitis model when the T-cells were harvested from GPR65−/− mice, however, the differential expression of inflammatory mediators between GPR65−/− and wild-type animals did not ameliorate the disease pathology [226].