During TRESK-MT transcription, fsATI leads to the production of a second protein fragment (MT2) that inhibits TREK1/TREK2 activity increasing sensory neuronal excitability in trigeminal neurons, i.e. both non-functional TRESK-MT and inhibition of TREK1/TREK2 are required to induce migraine-like pain states in mice [193]. Here, KCNK2 is linked to migraine disorder.