Driven by this need, we here report a facile approach for the design of highly crystalline antibody-conjugated multifunctional multicolor-luminescence nanosystems derived from the naturally available popular tropical fruits mangoes and prunes, as shown in Schemes 1A and B, which have the ability to detect breast cancer heterogeneity via the selective separation and accurate identification of TNBC and HER-2(+) or ER/PR(+) breast cancer cells from a mixture. The gene discussed is ESR1; the disease is breast carcinoma.